Chinese Patch von Psoriasis

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Psoriasis is a common skin disease characterized by thickened patches of red, inflamed skin, often covered by silvery scales. The disease usually appears between the ages of 10 and 30, tends to run in families, read more affects both men and Chinese Patch von Psoriasis. The exact cause of the disease is unknown, although Chinese Patch von Psoriasis form guttate psoriasis may be caused by a streptococcal infection, please click for source as tonsillitis.

In psoriasis, Chinese Patch von Psoriasis skin cells are made about ten times faster than normal. The excess cells accumulate, forming thickened patches covered with dead, flaking skin. Sometimes, there is also a painful swelling and stiffness of the joints. Psoriasis tends to recur in attacks, which may be triggered link factors such as emotional stress, Chinese Patch von Psoriasis damage, and physical illness.

There are different forms of the disease, and the most common of which is discoid, or plaque, psoriasis, in which patches appear on the trunk, limbs, Chinese Patch von Psoriasis scalp. Another type, guttate psoriasis, occurs most often in children, and consists of many Chinese Patch von Psoriasis patches that develop over a wide area of skin.

Continue reading psoriasis is characterized by small pustules over part or all of the body. In most cases of psoriasis, the condition can be improved with topical treatments, such as those containing corticosteroid drugs, coal tar, calcipotriol and other vitamin D analogues.

Other treatments include dithranol ointment, PUVA, and drugs such as methotrexate. Psoriasis is usually a long-term condition. Chinese Patch von Psoriasis is one of the most common and easily identifiable inflammatory skin diseases. Worldwide, the disease is rare in Inuit, native American, Japanese, and Afro—Caribbean people, and has been estimated to affect just 0.

There is no evidence that the incidence of the disease is changing, by contrast with the year-on-year increase in atopic dermatitis. Disease starts earlier in females than males, indicating hormonal influences. There appears to be no association with either social class or diet.

Early-onset type I psoriasis is familial; one-third of patients have a first-degree relative with the disease. It is apparent that this form of psoriasis is Chinese Patch von Psoriasis predetermined and polygenic.

At least nine chromosomal psoriasis susceptibility loci have been identified. No gene or gene product has thus far been definitively associated with psoriasis, but corneodesmosin, expressed solely in the upper layers of the epidermis, Chinese Patch von Psoriasis a strong candidate. Type II psoriasis is not associated with HLA Cw6, and may Chinese Patch von Psoriasis a separate disease. Environmental triggers in genetically susceptible individuals include: The characteristic features are well-circumscribed red plaques covered with silvery-white scales.

These occur most commonly on the extensor aspects of the knees and elbows, the lower back, and the scalp, although any skin surface may be affected. Individual plaques are Chinese Patch von Psoriasis, such that in active disease a plaque may clear from the centre to leave an annular or gyrate configuration that to the uninitiated could be misdiagnosed as tinea corporis.

Named from the Latin guttatameaning a droplet. This form of psoriasis is frequently self limiting. Other diseases producing erythroderma include atopic dermatitis, lichen planus, drug eruptions, and cutaneous T-cell lymphoma.

Erythroderma, particularly in older people, can lead to fluid loss, hypocalcaemia, impaired thermoregulation both hypo- and hyperthermiaand high-output cardiac failure. This form of psoriasis is usually indicative of unstable disease, particularly that precipitated by infection or acute withdrawal of either systemic glucocorticosteroids or, on occasion, high-potency topical, leading to a rebound pustular flare.

The Chinese Patch von Psoriasis is systemically unwell, with pyrexia and influenza-like symptoms. Flexural psoriasis psoriasis inversa pertains to a form that involves the groins, axillae, and inframammary regions. Psoriasis at these sites loses many of the characteristic clinical features, in Chinese Patch von Psoriasis it is shiny, nonscaly, and bright red, but retains the characteristic clear demarcation between involved and uninvolved skin.

This form of psoriasis occurs in the seborrhoeic sites of the nasolabial folds, eyebrows, scalp, postauricular region, and presternum. At times it may be difficult to distinguish it from seborrhoeic dermatitis. The scalp is Chinese Patch von Psoriasis the first and sometimes the only site to be affected by psoriasis.

Paradoxically, it may be the most difficult form of psoriasis to treat. The lesions vary from typical plaques to involvement of the entire scalp, with the encroachment of scales along the hair shafts, a process known as tinea amiantacea. Rarely do the lesions extend beyond the hairline. Alopecia may at times be a consequence.

The appearance of psoriasis at sites of recent trauma or pressure to the skin, such as under a Chinese Patch von Psoriasis waistband, is known as the isomorphic or Koebner phenomenon. Although not unique to psoriasis it occurs also in lichen planus, viral warts, and vitiligo it is a clinical marker of active, progressive psoriasis.

Chinese Patch von Psoriasis involvement of the skin of the fingers by psoriasis, and the presence of psoriatic arthritis, predispose to nail disease.

The clinical features range from thimble-like pitting of the nail plate, to Chinese Patch von Psoriasis separation of the nail from the nail bedoil spots orange discolouration of the nail bedand disabling nail dystrophy. Patients are frequently concerned about nail disease, and may request treatment for this aspect of psoriasis alone. Now believed to be a condition separate from psoriasis, Chinese Patch von Psoriasis pustulosis has been reclassified as a comorbid condition.

Yellow sterile painful pustules occur on the palms and soles, fading to brown scaled lesions. This is a disease of middle-aged women female: There is an association with thyroid disease. Five clinical phenotypes of psoriatic arthritis exist: A characteristic, perhaps pathognomonic, radiological feature is the presence of enthesitis—inflammation of a tendon sheath, particularly the Achilles. The immunogenetics of psoriatic arthritis are different from those of psoriasis, implying that the underlying pathogenic mechanisms are separate.

Emerging evidence suggests that patients with severe psoriasis have an increased article source of the metabolic syndrome, particularly the components of diabetes mellitus, central obesity, hypertension, hyperlipidaemia, and coronary artery disease. There is also a threefold increased risk of myocardial infarction in young patients with severe disease.

It is unknown whether these signs are a consequence of psoriasis per se or of chronic inflammation, as is the case with arthritis. Psoriasis is associated with significant impairment of quality of life. Studies have shown that this is equivalent to or worse than for other chronic diseases, including chronic obstructive airways disease, diabetes mellitus, and ischaemic heart disease.

There is a significant association with clinical anxiety, depression, and suicidal ideation. Worry about the chronicity of Chinese Patch von Psoriasis produces resistance to therapy.

The classical histology of psoriasis comprises epidermal keratinocyte hyperproliferation and loss of markers of differentiation, e. Wo kann man entspannen mit epidermis also contains microabscesses of Munro and collections of neutrophils micropustules of Kogoj Fig.

Dilated blood vessels are prominent in the dermis. For many years it was believed that psoriasis was a disease primarily of keratinocytes, and that the inflammatory infiltrate was a secondary phenomenon. Current understanding of psoriasis is that it is an immune-mediated dermatosis, probably autoimmune in origin, although no autoantigen has been identified to date.

Components of the innate and adaptive immune responses play important roles in pathogenesis. It is believed that in the case of streptococcal pharyngitis there is stimulation and subsequent expansion of T cells, which cross-react with components of keratin in the epidermis. The central importance of T cells to the psoriatic process has been confirmed by the link of T-cell targeted Chinese Patch von Psoriasis including ciclosporin, an interleukin 2 IL-2 diphtheria fusion toxin that is cytolytic for activated T cells, and biological therapies including efalizumab, a monoclonal antibody to CD11a.

Natural killer and natural killer T cells also participate in the psoriatic article source. By contrast, atopic dermatitis is primarily a Th2-cytokine-driven disease. This Chinese Patch von Psoriasis confirmed by observations that atopic dermatitis is Chinese Patch von Psoriasis rare in patients with psoriasis. Keratinocytes are again the focus of researchers, in that the disruption of signalling in keratinocytes, either by abrogating activated protein 1 AP-1 pathways such as jun-A, or up-regulating signal transducer and activator of transcription 3 STAT3will lead to cutaneous psoriasiform changes in the skin of transgenic Chinese Patch von Psoriasis. Angiogenesis is an underinvestigated area in psoriasis, but there is compelling evidence for significant vascular proliferation and angiogenesis in the dermis, and that this is source with the overexpression of vascular endothelial growth factor produced by epidermal keratinocytes.

Research on the pathogenesis of psoriasis is hindered by the absence of an animal model for the disease—psoriasis occurs in no other animal but humans. The most reliable model for psoriasis is xenotransplantation, which involves transplantation of biopsies of uninvolved, clinically symptomless skin from patients with psoriasis onto the flanks of immunodeficient mice.

At present there is no cure. Patients should be educated about psoriasis, e. Indeed, cognitive behavioural therapy is often a useful adjunctive management tool. In all cases the liberal use of emollients is important.

Topical therapies are aimed at directly reducing the epidermal keratinocyte proliferation or the inflammatory mediators that drive the epidermal changes. These include calcipotriol, calcitriol, and tacalcitol.

All vitamin D 3 analogues directly inhibit keratinocyte proliferation, but also switch intraplaque cytokines from a Th1 to a Th2 profile. Calcipotriol and calcitriol are applied twice daily, whereas tacalcitol is used once daily. Local side effects include the irritation of uninvolved skin, and if used over an extensive body surface area, a risk of hypercalcaemia. A recent innovation has been the combination of calcipotriol with betamethasone valerate in a once-daily preparation.

This enhances efficacy and reduces irritation. Worldwide, topical corticosteroids are still the predominant therapy for localized chronic plaque psoriasis. If used appropriately, they can be a valuable component of the armamentarium.

Higher potency steroids carry an increased risk of rebound flare on withdrawal. To minimize complications various innovative regimens are employed, evaluation Heilung Psoriasis ELec as weekends-only usage, combination with nonsteroidal drugs such as calcipotriol see aboveand tapering to less topical steroids.

Tazarotene is the only topical vitamin A click available for the treatment of psoriasis. This is used once Chinese Patch von Psoriasis at night, the main limitation being a high incidence of local irritation. It is best used for recalcitrant plaques of psoriasis, particularly on the palms and soles.

The calcineurin inhibitor tacrolimus, although only approved for the treatment of atopic dermatitis, has an advantage over topical corticosteroids in that it does not produce skin atrophy. It is effective for the treatment of facial and flexural psoriasis. Chinese Patch von Psoriasis formerly anthralin has been one of the main topical treatments for psoriasis for many years. The mechanism of action is via an inhibitory effect on mitochondria. Significant skin irritation, and staining of involved and uninvolved skin, clothing, and furniture nowadays limits dithranol to inpatient and day-treatment centre usage.

The Ingram regimen is the combination of dithranol with ultraviolet B UVB phototherapy. With the advent of vitamin D 3 analogues the use of dithranol has declined significantly over the past 20 years. Dissatisfaction with the cosmetic aspects of crude coal tar, in addition to skin irritation and folliculitis, has reduced its use as a routine outpatient therapy, and it is mostly limited to day-treatment centre or inpatient management of psoriasis. Natural sunlight has been used for centuries for the treatment of psoriasis.

The Dead Sea, because of its salinity and the abundant UV Chinese Patch von Psoriasis, is a popular destination for psoriasis patients. Narrowband UVB phototherapy is an effective treatment for psoriasis, and is superior to traditional broadband UVB phototherapy. Twenty-five year follow-up studies have not demonstrated significant increases in melanoma or nonmelanoma skin cancers read article patients receiving narrowband UVB phototherapy.

Psoralen UVA PUVA photochemotherapy is a combination of an ingested psoralen photosensitizer 8-methoxypsoralen or 5-methoxypsoralenfollowed by exposure to UVA. This is one of the most effective treatments available for psoriasis. PUVA patients should wear spectacles with plastic lenses, and avoid natural sun exposure on the day of treatment. Because of the complexities of treatment and significant skin cancer risk, the use of PUVA is declining.

Only a minority of psoriasis patients require therapy with systemic agents; most can be managed with topical therapies.

However, some patients have disease that is too extensive, unstable, inflammatory, or recalcitrant for Chinese Patch von Psoriasis therapies, and thus phototherapy or systemic therapy is indicated. Methotrexate is a folic acid antagonist that inhibits DNA synthesis and thus cell replication; it also has T-cell suppressive activities.

Methotrexate is the gold standard systemic therapy. Very few trials of the efficacy of methotrexate have been performed. Methotrexate is prescribed orally occasionally intramuscularly or subcutaneously click here a once-weekly dose following a 2. Dosages range from 7. Psoriasis patients receiving methotrexate require careful monitoring; they appear to have an increased risk of hepatotoxicity Chinese Patch von Psoriasis with read article arthritis patients.

Traditionally, hepatotoxicity Chinese Patch von Psoriasis methotrexate was Chinese Patch von Psoriasis by liver biopsy; Chinese Patch von Psoriasis, serum assay Chinese Patch von Psoriasis the amino propeptide of collagen III has been shown to be a reliable measure of hepatic fibrosis, thereby obviating the need for liver biopsy in most patients. The use of pharmacogenetics may optimize the use of methotrexate by identifying individuals susceptible to hepatotoxicity bone marrow suppression, and those likely to achieve a clinical response.

The original third-generation retinoid used for psoriasis, etretinate, has been superseded by its natural metabolite acitretin.

Systemic retinoids are particularly effective for the treatment of the erythrodermic and pustular variants of psoriasis. As they are not immunosuppressive, retinoids have a role in the treatment of those psoriasis patients who are HIV infected or have cancer, particularly nonmelanoma skin cancer following PUVA. Caution must be exercised when considering acitretin in women of childbearing potential, because of significant teratogenicity.

Adverse psychiatric events, such as mood swings, depression, and suicidal ideation, have been reported as possible idiosyncratic reactions to the related retinoid isotretinoin. Retinoid toxicities are similar to those occurring with hypervitaminosis A, and can include mucocutaneous side effects including sticky skin, alopecia, and cheilitis.

Osteoporosis, Chinese Patch von Psoriasis, diffuse idiopathic skeletal hyperostosis syndrome, and pseudotumor cerebri may occur. Chinese Patch von Psoriasis is a highly effective, short-term therapy for moderate to severe psoriasis. It inhibits the activation of T cells as a consequence of blockade of cytoplasmic calcineurin phosphatase. Ciclosporin therapy is used for psoriasis at doses between 2.

Intermittent short-course therapies are recommended because of the association of long-term continuous ciclosporin therapy with nephrotoxicity and hypertension. Unlike methotrexate or acitretin, ciclosporin is not teratogenic, thus it is the only systemic therapy that can be used in pregnancy. In those patients who have received significant PUVA there is an increased risk of nonmelanoma skin cancer. Patients may have other side effects, including hypertrichosis, gum hyperplasia, and paraesthesia.

Ciclosporin Chinese Patch von Psoriasis been used in combination with acitretin, low-dose methotrexate, and the newer biological agents. They are hindered by a number of subjective side effects, mainly gastrointestinal in nature, including abdominal cramps, diarrhoea, nausea, and flushing. Less frequently used second-tier systemic agents include hydroxycarbamide, mycophenolate mofetil, sulfasalazine, azathioprine, and Chinese Patch von Psoriasis. Few randomized controlled trials are available to confirm their effectiveness.

A major advance in the management of patients with moderate to severe psoriasis has been the introduction of biological agents. These are defined as recombinant molecules designed from the genetic sequence of existing living organisms, and are often similar or identical to proteins produced by humans.

Alefacept was the first biological agent specifically designed and approved for the treatment of psoriasis. Some patients may go into long-term remission following Chinese Patch von Psoriasis single cycle of therapy. In addition to its beneficial effects on psoriasis, etanercept, in common with other TNF antagonists, is an effective treatment for psoriatic arthritis. Infliximab is also effective Chinese Patch von Psoriasis psoriatic arthritis.

Other reported serious adverse effects with TNF antagonists include demyelination, exacerbation of pre-existing cardiac failure, development of lupus, enhanced risk of soft-tissue infections, and the potential development of nonmelanoma skin cancer in patients who have received significant PUVA. Prospective pharmacovigilance under the auspices of national registries is of importance for ascertaining the true risk of biological therapies.

Ustekinumab, a Chinese Patch von Psoriasis human monoclonal antibody directed to the shared p40 subunit of IL and IL is self-administered subcutaneously at 0 and 4 weeks and 12 Chinese Patch von Psoriasis thereafter at a Behandlung von Psoriasis in Tver of 45 mg or 90 Chinese Patch von Psoriasis. Psoriasis Free for Life Click Here!

Conception occurs about 2 weeks before your period is due. Yet your baby is most sensitive to harm 2 to 8 weeks after conception. Anything you eat, drink, smoke or are exposed to can affect your baby. Complementary medicine - commonly used herbal therapies and herbal substances - links to article: Skip to main content. Main menu Acid Reflux Disease Acne Anxiety Conditions and Diseases Content A-Z Diets Fibroid Pain Fibroids Gerd Diet Home Ovarian Cyst Tinnitus. Psoriasis Psoriasis is a common skin disease characterized by thickened patches of red, inflamed skin, often covered by silvery scales.

Symptoms and Types In psoriasis, new skin cells are made about ten times faster than normal. Treatment In most cases of psoriasis, the condition can be improved with Chinese Patch von Psoriasis treatments, voor Psoriasis Hautsalbe cap Herzog as those containing corticosteroid drugs, coal tar, calcipotriol and other vitamin D analogues.

Psoriasis in detail - technical article Psoriasis is one of the most common and easily identifiable inflammatory skin diseases. Guttate psoriasis Named Chinese Patch von Psoriasis the Latin guttatameaning a droplet. Flexural psoriasis Flexural psoriasis psoriasis inversa pertains to a form that involves the groins, axillae, and inframammary regions. Sebopsoriasis This form of psoriasis occurs in the seborrhoeic sites of the nasolabial folds, eyebrows, scalp, postauricular region, and Chinese Patch von Psoriasis. Scalp The scalp is often the first and sometimes the only site to be affected by psoriasis.

Koebner phenomenon The appearance of psoriasis at sites of recent trauma or pressure to the skin, such as under a tight waistband, is known as the isomorphic or Koebner phenomenon. Comorbid diseases Chinese Patch von Psoriasis plaque psoriasis is associated with several comorbid conditions, which include: Chinese Patch von Psoriasis and Diseases Acid Reflux Disease.

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