Die anfängliche Behandlung von Psoriasis Äußerliche Behandlung der Schuppenflechte Die anfängliche Behandlung von Psoriasis


Psoriasis arthritis - Schuppenflechte in den Gelenken - Psoriasis Forum Berlin e.V. Die anfängliche Behandlung von Psoriasis

Try the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents. Stabile Gelzusammensetzung zur topischen Behandlung von Hautkrankheiten Stable gel composition for topical treatment of skin diseases translated from German DE T2. The formulation of claim 1, wherein the variety is selected from non-aqueous vehicles under any of: A formulation according to claim 1 or 2, wherein the vehicle are present in amounts selected to cause maximal release of the active agent from the gel when all the vehicles are present therein.

A formulation according to any of the preceding claims, wherein the formulation comprises three vehicles. The formulation of claim 1, wherein the vehicle are present in quantities Die anfängliche Behandlung von Psoriasis are selected, a maximum solubility of the active agent in the gel to produce. Formulierung nach Anspruch 1 oder Anspruch 5, worin die Formulierung zwei Die anfängliche Behandlung von Psoriasis umfasst.

The formulation of claim 1 or claim 5, wherein the formulation comprises two vehicles. Formulierung nach Anspruch 1 oder Anspruch 5, worin drei Vehikel verwendet werden, Die anfängliche Behandlung von Psoriasis sowohl das aktive Agens zu solubilisieren als auch ein Gel zu bilden. The formulation of claim 1 or claim 5 wherein three vehicles are used to both solubilize the active agent and form a gel.

The present invention relates to a stable Die anfängliche Behandlung von Psoriasis formulation for topical treatment of both acne and psoriasis in humans. Acne is a relatively common inflammatory disease that affects the skin. The severity of the disease ranges from a http://festival-celle.de/naftalan-salbe-fuer-psoriasis.php or less superficial disorder to inflammatory conditions in which bacterial infection occurs, which causes an occurrence of inflamed and infected bubbles.

The greatest activity occurs where sebaceous glands are largest, most numerous and naturally active. The acne lesions dilate, if untreated, and leave permanent disfiguring scars. The cause of acne is increased activity of the sebaceous glands and the epithelial tissue, demonstrating the Infindibulum. The increased activity of the sebaceous glands produces more sebum, as well as the non-saponifiable fat ingredients consists of free and esterified fatty acids, resulting in increased skin oiliness.

In inflammatory acne, the initial inflammation of Haarfollikelwandungen on the presence of free fatty acids is due, derived Die anfängliche Behandlung von Psoriasis the sebum. In the presence of bacterial lipolytic enzymes, triglycerides of the sebum are split and the released fatty acids. The Die anfängliche Behandlung von Psoriasis bacterial flora in the Talgduktus produces the enzymes that are responsible for cleavage of the triglycerides.

Current treatments for acne include comedolytic agents, exfoliants, oral and topical antimicrobials, as well as systemic antibiotics. Ideally, topical formulations for the treatment of acne with little or no oil to be assembled in the formulation and leave no oily film on the skin, causing the skin condition Psoriasis, wie erscheint auf den Beinen worse.

Psoriasis on the other hand is a chronic, hereditary recurrent papulosquamous dermatosis usually the scalp and the extensor surfaces of the limbs involving, in particular the elbows, knees and shins. The distinctive lesion of psoriasis is a bright red spot papule or plaque, which is almost always covered at its edge by silvery scales laminated. Psoriasis is further characterized by accelerated epidermal proliferation, resulting in excessive scaling of the skin due to the fact that psoriatic skin loses water eight to ten times Die anfängliche Behandlung von Psoriasis than normal skin.

For this reason, topical treatment it usually contains oils which are best suited in order to moisturize the skin. Stable aqueous gel vehicle are described which share for topical application to the skin of irritating active ingredient, such as retinoids, are provided with slow treatment Biotin bei der Behandlung von Psoriasis venous of the active ingredient and minimal irritation to Psoriasis als von zur Behandlung Frakturen bei skin.

The present invention relates to a stable gel formulation that does not contain any oil and therefore Die anfängliche Behandlung von Psoriasis the requirements of treatment and also offers a high humidified factor for psoriatic treatment.

Effectiveness of an active agent for treatment of acne and psoriasis naturally depends on the availability of the agent for affected areas if used in a topical manner. That is, the formulation contains sufficient not only active agent to treat the condition suitable, but also the release of the active agent from the formulation is an absolute necessity.

According to the invention, a gel formulation has been developed which is suitable for treatment of both acne and psoriasis includes the vehicle to both solubilize the active agent and a release of the active agent to control from the gel to the skin condition. According to the invention, a stable gel formulation for topical treatment of skin conditions in humans is provided, comprising an active agent which is a synthetic retinoid having activity for treatment of acne and psoriasis and is insoluble in water.

Along with this, combining a plurality of nonaqueous vehicles selected from two or more of polysorbate 40 a polyhydroxyorganischen compoundpoloxamer and hexylene glycol for both solubilizing the active agent or disconnect as well as to form a gel therewith. The non-aqueous vehicles enable topical application of the gel to a skin condition.

Preferably, the vehicles are present in amounts selected to produce the highest possible release of the active agent from the gel to the skin condition when all the vehicles are present therein. Die anfängliche Behandlung von Psoriasis combinations of the vehicles provide a means to increase the solubility of the active agent in the gel prepared. Die Formulierung umfasst insbesondere drei Vehikel. In particular, the formulation comprises three vehicles. Das synthetische Retinoid ist vorzugsweise Ethyl[2- 4,4-Dimethylthiochromanyl] Nikotinat oder eines der anderen synthetischen Retinoide, die in den US Patenten 4,; 4,; 4,; 5,; 4,; 5,; 4,; 5,; 5,; 5, und 5, offenbart sind.

The synthetic retinoid is preferably Ethyl [2- 4,4-dimethylthiochromanyl] nicotinate or any of the other synthetic retinoids disclosed in U. Patents 4,; 4,; 4,; 5,; 4,; 5,; 4,; disclosed 5, and 5,; 5,; 5, Zum Zweck einer Veranschaulichung kann eine stabile Gelformulierung mit einer effektiven Menge einer Verbindung die Formulierung aufweisen: For purposes of illustration, the formulation may comprise a stable gel formulation having an effective amount of a compound: Ethyl [2- 4,4-dimethylthiochromanyl] nicotinate, sometimes referred to inferior as AGN for treating acne in a pharmaceutical carrier comprising water, edetate disodium, ascorbic acid, Carbomer P, Poloxamerpolyethylene glycol, Polysorbate 40, hexylene glycol, butylated hydroxytoluene, butylated hydroxyanisole, benzyl alcohol, and tromethamine comprises.

For purposes of illustration, a method for preparing a formulation for topical treatment of both acne and psoriasis the steps of mixing purified water, edetate disodium, ascorbic acid and Carbomer P a polyacrylic acid until the carbomer is dispersed to form a part Imixing purified water, poloxamer to form a part II and adding part II to Part I, while the same is homogenized.

The method further includes mixing polyethylene glycol, Polysorbate 40, hexylene glycol, butylated hydroxytoluene and butylated hydroxyanisole and heating to dissolve same. Thereafter, the heated mixture is cooled to room temperature and benzyl alcohol and Ethyl Die anfängliche Behandlung von Psoriasis 4,4-dimethylthiochromanyl] nicotinate are added thereto to form a part III. Purified water is mixed with tromethamine to form part IV and Part III is added to parts I and II while stirring before part IV with mixing until homogeneous.

Die Vorteile und Eigenschaften der vorliegenden Erfindung werden durch die nachstehende Beschreibung besser verstanden werden, falls im Zusammenhang mit den begleiteten Zeichnungen betrachtet, die wie nachstehend bezeichnet sind: The advantages and characteristics of the present invention will be better understood from the following description when considered in conjunction with the accompanying drawings, which are designated as follows: Ordinary plot of residuals for the solubility data.

Response surface fitting the solubility data with hexylene glycol. Ordinary graphical representation of remaining in the release of data. Wirkung einer Transformation der Antwort Freisetzungsdaten ; Effect of a transformation of the response release data. Response surface fitting the release data with hexylene glycol.

Release profiles showing the effect of increasing the concentration of drug in the gel vehicle on the released rate, 0. The following factors must be involved in the formulation of a suitable pharmaceutical preparation for the treatment of acne and psoriasis: Formulierungs- und Patientenzustimmungsfragen Formulation and patient consent issues. Es wurde gefunden, dass die Verbindung Ethyl[2- 4,4-Dimethylthiochromanyl] Nikotinat bei der Behandlung von Akne und Psoriasis wirksam ist.

It has been found that the compound Ethyl [2- 4,4-dimethylthiochromanyl] nicotinate is active in the treatment of acne and psoriasis. The solubility of AGN in water is very low. As noted above is a Die anfängliche Behandlung von Psoriasis, AGN soluble dosage form is not desirable in terms of the water content, the difficulty with handling of the solution and apply to the skin. A cream formulation is applicable, but the oil used therein is not also suitable for acne treatment as noted above.

The formulation according to the present invention comprises a number of components, such as are set forth in Table II. Tabelle II Verwendete Bestandteile bei einer Formulierung eines AGN Gels Table II components used Psoriasis auf den Händen a formulation of an AGN gel. The rationale for selection of the excipients used in the AGN topical gel is outlined below.

Polyethylenglycol wird in AGN topischer Gelformulierung als ein Solvens zur Solubilisierung des aktiven Arzneimittels, AGN, verwendet. Polyethylene glycol is used in AGN topical gel formulation as a solvent to solubilize the active drug, AGN. Solubility of AGN in PEG is 2. At ambient conditions PEG is a liquid that is Die anfängliche Behandlung von Psoriasis miscible with water, the topical formulations may be simply mixed.

PEG is chemically stable and does not support microbial growth. PEG ist hygroskopisch und topische Formulierungen, die mit PEG zubereitet sind, trocknen nicht unmittelbar nach Anwendung auf die Haut. PEG is hygroscopic and topical formulations prepared with PEG do not dry immediately after application to the skin. Die nachstehenden vermarkteten RX Produkte in den USA umfassen PEG als Excipient: The following RX marketed products in the United States include PEG as excipient: PEG ist ein Bestandteil von "Polythylenglycolsalbe NF".

PEG is a component of "Polythylenglycolsalbe NF". Carbomer P is used as viscosity producers in AGN topical gel formulations. Carbomer P has the ability to produce high viscosities at low Die anfängliche Behandlung von Psoriasis after neutralization, with much greater lot to lot consistency than the natural gums and does not support microbial growth.

Carbomer P Psoriasis Kokosöl show good plastic flow properties, have generally defined as the initial resistance to flow under imposed load to a significant yield value. AGN topisches Gel, read more mit Carbomer P hergestellt ist, zeigt eine annehmbare Dicke bzw.

AGN topical gel, which is prepared with carbomer P, shows acceptable thickness and density and evenly distributed upon application to the skin. Edetate disodium is used in AGN topical gels as a gelling agent for the stabilization of the overall formulation. Trace amounts of iron and other transition metals are known Carbopol resins used as a thickener and PEG used as solvent in AGN to decompose gel. Edetate disodium is used to sequester traces of metal ions which would oxidation of AGN and ascorbic acid used in the formulation catalyze.

Aqueous solutions of Polysorbate 40 are also known to undergo a autoxidation. Polysorbate 40 is used as surfactant to solubilize the AGN. Polysorbate 40 is liquid at ambient conditions, with PEG water miscible blends and clouding of the solution. Polysorbate 40 has an HLB value of Poloxamer is used as a surfactant in the water phase of the AGN gel formulation.

Poloxamer is water soluble and has an HLB value of Hexylenglycol ist mit Wasser PEG Mischungen mischbar und wird als Cosolvens zur Solubilisierung von AGN zusammen mit PEG verwendet. Hexylene glycol is miscible with water, PEG mixtures and is used as a cosolvent to solubilize AGN along with PEG Tromethamine is used during production of AGN topical gel to neutralize Carbomer P and to adjust the pH.

Ascorbic acid is used as an antioxidant and to the water phase added during manufacturing AGN topical gel. Laboratory formulation of AGN prepared without ascorbic acid which exhibit low stability.

Benzylalkohol wird zusammen mit PEG und Polysorbat 40 verwendet, um das aktive AGN zu solubilisieren. Benzyl alcohol is used along with PEG and Polysorbate 40 to solubilize the active AGN. Benzylalkohol wird ebenso als Konservierungsmittel verwendet. Benzyl alcohol is also used as preservative. Butylated hydroxytoluene, butylated hydroxyanisole are used in the AGN topical gel formulation as antioxidants protecting the overall product from residual peroxides found in excipients.

These antioxidants are not water soluble and are added to the PEG phase while manufacturing a. Nitrogen, as inert gas, is used during production of AGH topical gel to reduce any potential for autoxidation of the active ingredient and other excipients.

Gereinigtes Wasser wird als das Vehikel in der AGN topischen Gelformulierung verwendet. Purified water is used as the vehicle in the AGN topical gel formulation. Typische Konzentration von jedem Bestandteil in dem Gel wird in Tabelle III gezeigt. Typical concentration of each ingredient in the gel is shown in Table III. Die Bestandteile werden miteinander kombiniert, um die folgenden vier Teile zu erhalten: The ingredients are combined together to obtain the following four parts: Gereinigtes Wasser Purified water Die anfängliche Behandlung von Psoriasis Excipient Tromethamin Tromethamine Neutralisierungsmittel Neutralizing agent.

Verfahren zur Herstellung des Gels A process for the preparation of the gel. Das Verfahren zur Herstellung des Gels ist wie nachstehend: The process for the preparation of the gel is as follows: Die Bestandteile in Teil I werden bei Homogenisierung von geringer Geschwindigkeit gemischt bis das Carbomer dispergiert ist.

The items in Part I are mixed at low speed until homogenization of the carbomer is dispersed. Die Bestandteile in Teil II werden gemischt. The components in Part II are mixed. Teil II wird zu Teil I hinzu gegeben und die Mischung wird homogenisiert. Part II is added to Part I added and the mixture is homogenized. The first four ingredients in part III are combined and heated to 65 degrees Celsius until all compounds are dissolved. The mixture is allowed to cool to room temperature.

Is with mixing in the yellow room benzyl alcohol and the drug then added together slowly. The ingredients in part IV are combined and added to the above mixture and mixed until homogeneous. Unter Verwendung einer Versuchsanordnung wurden Variationen des Gels formuliert, welche Polysorbat 40 und Poloxamerjeweils bei drei Werten, und Hexylenglycol bei zwei Werten umfassten. Using an experimental design variations of the gel were formulated which included Polysorbate 40 and poloxamereach at three levels, and hexylene glycol at two values.

Based on this 2 x 2 factorial arrangement 3 eighteen variations of the gel were formulated and evaluated the effect of surfactant and cosolvent concentration on drug solubility and in vitro release. Brookfield counter-rotating mixer Brookfield Engineering laboratories Inc.

Herstellung von Versuchsgelen Production of Versuchsgelen. Die in dem Prototypgel verwendeten Bestandteile Formulierung X werden in Tabelle III gezeigt. The ingredients used in the Prototypgel X formulation are shown in Table III. Basierend auf Versuchsanordnung wurden Variationen des Prototypgels hergestellt, welche verschiedene Konzentrationen von drei Bestandteilen, die in Die anfängliche Behandlung von Psoriasis Gel vorliegen, umfassten; Based on experimental design variations of the Prototypgels were prepared which comprised various concentrations of three ingredients present in the gel; Polysorbat 40 PSPoloxamer PX und Die anfängliche Behandlung von Psoriasis HG.

Polysorbate 40 PSpoloxamer PXand hexylene glycol HG. The purpose was to study the effect of these factors on the release rate and solubility of AGN in the vehicle of the gels. The process for the preparation Die anfängliche Behandlung von Psoriasis the gels is http://festival-celle.de/psoriasis-novosibirsk-1.php in the formulation report.

Experimental design and experimental setup was used to determine the number of necessary this web page to provide the desired information in the most effective manner.

Die untersuchten Variablen waren die Konzentrationen von Hexylenglycol, Poloxamer und Polysorbat Die anfängliche Behandlung von Psoriasis wurde bei zwei Werten bzw.

The variables studied were the concentrations of hexylene glycol, poloxamerand polysorbate Table IV shows the actual concentrations used for each of these ingredients. For all ingredients, the concentration of Psoriasis die an leiden entwickeln kann Krebs indicates that the ingredient Die anfängliche Behandlung von Psoriasis not present.

The levels of poloxamerpolysorbate 40, and hexylene glycol, for the production of the different. Die Versuchsanordnung wird in Tabelle V gezeigt. The experimental arrangement is shown in Table V. This arrangement required the production of eighteen gels all Psoriasis und Vitiligo Zentrum cross comprised all possible combinations Die anfängliche Behandlung von Psoriasis the surfactants and co-solvent at the desired values.

Da das Prototypgel Gel B eines dieser Gele darstellte, war es notwendig, siebzehn weitere Gele zu formulieren. Since the Prototypgel gel B represented one of these gels, it was necessary to formulate seventeen more gels.

Formulations comprising less than two of polysorbate 40, include poloxamer and hexylene glycol, are included only for Die anfängliche Behandlung von Psoriasis purposes with. Solvent systems comprising the same ingredients as Die anfängliche Behandlung von Psoriasis gels were prepared in order to determine the saturated solubility of the drug in the vehicle of each of the 18 gel formulations.

The saturated solubility was determined once in solutions of the vehicle without carbomer and base, and another time by substituting propionic acid for carbomer in order to simplify as possible while maintaining the ionic strength of the solution as close to the gel filtration of the solution.

The solutions were filtered through a 0. The resulting solutions were then diluted and their Die anfängliche Behandlung von Psoriasis content was carried out using high pressure liquid chromatography HPLCas described in Method HL examined. Freisetzung von AGN von den Gelen Release of AGN from the gels.

The release of AGN through each of the 0. The collected fractions were then analyzed directly using HPLC Method HL Steigungen der Freisetzungsprofile Slopes of the Release Profiles. For each release profile, the slope of the linear region containing at least 6 points was calculated using linear Die anfängliche Behandlung von Psoriasis. The standard deviation and correlation coefficient of each slope was also calculated.

The difference between the slopes and solubilities from gel to gel were analyzed using a two-tailed t-tests to find the gels that lead to significantly different values. Maximierung von Solubilisierung und Freisetzung Maximization of solubilization and release. Initially the slope was maximized to find the Die anfängliche Behandlung von Psoriasis which had the maximum drug release, then the solubilization was maximized to find the gel which had the highest drug solubility.

Finally, both solubilization and slope Die anfängliche Behandlung von Psoriasis simultaneously maximized to find the gel, which provided the best drug release and solubilization. In order to determine whether the dissolution rate of the particles limiting the drug release rate, the data were obtained from the in vitro release study was analyzed.

Membranwirkung auf Arzneimittelfreisetzung Membrane effect on drug release. To investigate the possibility that the silicone membrane being rate limiting, the slope of the release profile for drug diffusion through the gel with the slope of the release profile was compared to that obtained from a saturated solution of the drug.

Wirkung von Arzneimittelkonzentration auf Freisetzungsrate Effect of drug concentration on release rate. Release study was conducted which shows the influence of drug concentration on the in vitro release of AGN from three gel formulations. The three gels showed formulations X 0. Ergebnisse und Diskussion Results and discussion. The solubility of the drug was determined in the vehicle of the Prototypgels gel B and all the other formulated gels in order to investigate the effect of the surfactants and Die anfängliche Behandlung von Psoriasis addition on the Arzneimittelsolubilisierung in the gel.

Formulations comprising less than two of polysorbate 40, include poloxamer and hexylene glycol, are included only for comparison purposes. Der einzige Unterschied zwischen Gelen 3 und 10 bestand in der Konzentration von Hexylenglycol. The only difference between gels 3 and 10 was the concentration of hexylene glycol. The t-test Table VII indicated that the addition of surfactant resulted in a significant increase in drug solubility.

These gels were 5, 6, 11, 12, 13, 16, 17 and 18, which have the highest levels of surface active agents included Table V. The goal was to find the combination of polysorbate 40, poloxamer and Hexylenglycolkonzentrationen, which led to the maximum drug solubility within the range of the investigated factors. Worksheet eingetragen, wurde ein Model an die Daten gefittet.

Were once the data for the factors and responses recorded on Die anfängliche Behandlung von Psoriasis worksheet or Worksheet, a model was fitted to the data. Tabelle VIII zeigt die kleinsten Quadratkoeffizienten. Table VIII shows the least squares coefficients.

Von der Tabelle ist es klar, dass zwei der Interaktionsterme die Hexylenglycol einbeziehen, nicht signifikant sind. From the table it is clear that two of the interaction terms involving hexylene glycol are not significant. Daher wurden diese beiden Terme ausgeschlossen. Therefore, these two terms were excluded. The least square coefficients for the improved model are shown in Table IX. The smallest square coefficient of solubility. Das Model wurde einfacher. The model was simple. Die Gleichung, welche die Daten fittet ist: The equation which is fittet the data: Irgendeine Art von Zusammenhang kann den Bedarf anzeigen, die Antwort zu transformieren.

Some sort of connection may indicate the need to transform the response. Die graphische Darstellung legt nahe, dass kein klarer Trend bei den Resten vorliegt, und dass das Model keiner Verbesserung bedarf.

The graph suggests that no clear Die anfängliche Behandlung von Psoriasis in the radicals present, and that the model does not require any improvement. To determine if the model can be improved by transforming the response, the fitting of the model is checked. The transformation that results in the smallest value for this number produces the best fitting and the best fit.

Da die nicht transformierte Antwort unterhalb der Linie liegt, wurde die Antwort nicht transformiert. Since the untransformed response is below the line, the response was not transformed. An optimization was performed to determine the factors levels which result in maximum drug solubility.

As can be seen from Table X, when a gel is prepared which contains between 0 to 0. Arzneimittelfreisetzung wurde von allen siebzehn formulierten Gelen, wie vorstehend beschrieben, untersucht. Drug release was studied from all seventeen formulated gels as described above. Die Freisetzungsprofile dieser Gele werden in den The release profiles of these gels are in the 5 5 — - 8 8 gezeigt.

Freisetzungsstudien von hergestellten Gelen Release studies of prepared gels. The highest release rate was observed for the Prototypgel containing 0. The observed variation in each run average was approximately 5. Der Wert der berechneten Steigungen wird in Tabelle XI gezeigt. The value of the calculated slopes are shown in Table XI. Steigungswerte, die von den Freisetzungsprofilen der formulierten Gele berechnet wurden Slope values, calculated from the release profiles of the formulated gels.

Statistische Analyse der Steigungsdaten Statistical analysis of the slope data. The t-test Table Die anfängliche Behandlung von Psoriasis indicated that the addition of surfactant in a significant increase in the release of the drug from gel B.

In addition, the t-test showed that Die anfängliche Behandlung von Psoriasis release of drug from the reference gel was significantly higher than most gels except gel 6 0. The goal was to find the combination of polysorbate 40, poloxamer and Hexylenglycolkonzentrationen, they led to a maximum drug release in the range of studied factors.

Ein Model, das Interaktionsterme umfasste, wurde an die Freisetzungsdaten gefittet. A model that included interaction terms was fit to the data release. Die Gleichung wird nachstehend gezeigt. The equation is shown below. Tabelle XIII zeigt die kleinsten Quadratkoeffizienten. Table XIII shows the least squares coefficients. Von der Tabelle ist es ersichtlich, dass die Interaktionskoeffizienten nicht wesentlich waren.

From the table it is apparent that the interaction coefficients were not significant. Jede Gruppe wurde getrennt analysiert. Each group was analyzed separately. Zuerst wurden die Freisetzungsdaten von den neun Gelen, die kein Hexylenglycol umfassten, analysiert. First, the release data were analyzed by the nine gels, which included no hexylene glycol.

Ein quadratisches Die anfängliche Behandlung von Psoriasis wurde verwendet, um die Freisetzungsdaten zu fitten. A quadratic model was used to fit the release data. Tabelle XIV zeigt die kleinsten Quadratkoeffizienten. Table XIV shows the least squares coefficients. Die Gleichung wird nachstehend gezeigt: The equation is shown below: The smallest square coefficients for release rate data gels not include hexylene glycol.

Wie aus der Tabelle ersichtlich ist, sind die Interaktionsterme nicht wesentlich. As can be seen from the table, the interaction terms are not Die anfängliche Behandlung von Psoriasis. An exclusion of these terms leads to a linear model, the fittet the data is not good.

Dies zeigt an, dass learn more here ausreichenden Daten innerhalb den untersuchten Bereichen vorliegen, um ein geeignetes Model zu fitten.

This indicates that there are insufficient data are available within the investigated areas in order to fit a suitable model.

Die Gleichung, welche die Daten fittet, ist: The equation which fittet the data is: Die kleinsten Quadratkoeffizienten werden in Tabelle XV gezeigt. The least click the following article coefficients are shown in Table XV. Es ist ersichtlich, dass all die Interaktionsterme wesentlich sind. It can be seen that all the interaction terms are significant.

Die graphische Darstellung legt nahe, dass kein klarer Trend bei den Resten vorliegt und das Model keiner Verbesserung bedarf. The graph suggests that no clear trend in the radicals present and the model does not require any improvement. Eine normalwahrscheinlichkeitsgraphische Darstellung von den in A normal probability plot of the in 10 10 gezeigten Resten see more dass Punkte auf der graphischen Darstellung sehr nahe an die Linie fallen, was anzeigt, dass die Reste des Models normal verteilt sind.

The fitting or adapting of the model was checked to determine if Die anfängliche Behandlung von Psoriasis model can be improved by transforming the response.

Die Antwort wurde nicht transformiert, da die nicht transformierte Antwort unterhalb der Linie liegt. The response was not transformed, because the untransformed response is below the line. An optimization is performed to determine the levels of surfactants which result in maximum drug release rate.

Optimierung der Arzneimittelfreisetzungsrate Optimization of the drug release rate. A graphical representation of slope of release profile compared to the square root of solubility of drug in gel was carried out in order to investigate a possible correlation between drug solubility and the rate of drug release.

It was therefore concluded that in the tested range of surfactant and cosolvent, no correlation was present, which was observed between drug release and solubility. Drug Die anfängliche Behandlung von Psoriasis and release rate. This analysis was performed to determine the concentration of the two surfactants and Cosolvez which could be used to produce a gel with maximum solubility and release.

Dies stellt einen iterativen Vorgang dar. This is an iterative process. For this purpose, the slope was maximized while the range of solubility was constrained. Die Ergebnisse des Vorgangs werden in Tabelle XVII gezeigt. The results of the operation are shown in Table XVII. It was concluded, that can be obtained a maximum slope of The data obtained from the in vitro release study was analyzed Table XVIIIto determine whether the Die anfängliche Behandlung von Psoriasis rate of the particles limiting the drug release rate.

Therefore, it is concluded that the solubility of the drug particles in the gel is not rate limiting. Membraneffekt auf Arzneimittelfreisetzung Membrane effect on drug release. The slope of the linear portion of the curve for the gel was Therefore, this membrane was more info to serve as a suitable carrier membrane that offers no resistance to the drug diffusion.

Therefore, the in vitro release method has highlighted changes in drug release due to changes in drug http://festival-celle.de/salbe-fuer-psoriasis-999-bewertungen.php. The effect of varying the concentration of polysorbate 40, poloxamer and hexylene glycol on the release and solubility of AGN in a gel indicated that the gel has a maximum solubility and release of the drug, AGN.

This gel contained 0. Another gel was also identified, which had a drug solubility and drug release that were not significantly different from the Prototypgel. This second gel Gel 6 containing 0. All other components were available at the same concentration for both gels.

CAA1CACDED1DET2 Die anfängliche Behandlung von Psoriasis, DED1EPA1EPB1EPA1EPB1USUSWOA1. BiBTeXEndNoteRefMan. Gereinigtes Wasser Purified water. Carbomer P Carbomer P. Poloxamer Poloxamer Polysorbat 40 Polysorbate Butyliertes Hydroxytoluol Butylated hydroxytoluene. Butyliertes Hydroxyanisol Butylated hydroxyanisole.


TAZAROTEN UND UVB-PHOTOTHERAPIE ZUR BEHANDLUNG VON PSORIASIS - Allergan, Inc.

Die Creme befindet sich in der bequemen Tube mit dem Die anfängliche Behandlung von Psoriasis Deckel. Jetzt aller nach anderem, Die anfängliche Behandlung von Psoriasis man mit Hilfe dieser Creme der Krankheit der Haut genug schnell entgehen kann. Bei mir Psoriasis ist im jungen Alter erschienen. Erstens waren sie unbedeutend im Durchmesser und ich dachte, dass diese Erscheinungsform der allergischen Reaktion auf die Kleidung http://festival-celle.de/kraeutervolksheilmittel-fuer-psoriasis.php dem synthetischen Stoff.

Wendete viel Medikamente an, als juckende bei Kindern zu sie halfen mir nicht.

Es war wie nicht meine Haut. Die Kollegen auf der Arbeit haben mich begonnen, zu vermeiden. Bald hat der Direktor mich ohne konkreten Grund entlassen. In Wirklichkeit verstand ich, warum hat die Arbeit Die anfängliche Behandlung von Psoriasis. Das alles wegen Psoriasis. Es ist der Moment der Verzweiflung und der Unwissenheit angebrochen, wie es richtig ist, weiter zu handeln.

Eine meiner Freundinnen blieb richtigem ich bis zum Ende hat sich von mir nicht abgewendet. Wir suchten das Medikament von Psoriasis zusammen, bis Psorimilk gesehen haben. Ich habe ich zwei Tuben sofort bestellt. Ich cremte auf die Haut 2 Male im Tag — den Morgen und den Abend ein. Streng beachtete alle Forderungen, die in den Instruktionen angegeben sind. Die aktiven Hauptkomponenten der Creme Psorimilk ist der Extrakt des Wegerichs, des Schnellkrautes und das Produkt der Bienenzucht Propolis.

Jeder dieser Stoffe nach dem beeinflusst das Befinden der Haut. Durchschnittlich wird die Creme durch 10 Minuten nach seinem Auftragen eingesogen. Irgendwelcher eigenartiger Gegenanzeigen wird nicht beobachtet. Wenn auch ist Psoriasis schon seit langem geheilt, aber die dennoch innere Angst blieb noch. Nach der Heilung habe ich begonnen, anderen Menschen zu helfen, die von Psoriasis auch leiden. Die Creme kaufen es kann nur auf der offiziellen Webseite.

Nicht mehr muss man und hoffen auf das Wunder leiden, Die anfängliche Behandlung von Psoriasis Psoriasis verlorengehen wird genauso, wie erschienen ist. Welcher Effekt die Creme Psorimilk leistet Die aktiven Hauptkomponenten der Creme Psorimilk ist der Extrakt des Wegerichs, des Schnellkrautes und das Produkt der Bienenzucht Propolis. Schreibe einen Kommentar Antworten abbrechen.


Diagnose und Therapie der Psoriasis (Schuppenflechte)

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