Paul M Ridker, M. N Engl J Med ; Increased Behandlung von Psoriasis of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, we hypothesized that people with elevated high-sensitivity C-reactive protein levels but without hyperlipidemia might benefit from statin treatment.

Full Text of Background We randomly assigned 17, apparently healthy men and rapa für Psoriasis with low-density rapa für Psoriasis LDL cholesterol levels of less than mg per deciliter 3. Full Text of Methods The trial was stopped after a median follow-up of 1.

The rates of the primary end point were 0. Consistent effects were observed in all subgroups evaluated. The rosuvastatin group did not have a significant increase in myopathy or cancer but did have a higher incidence of physician-reported diabetes. Full Link of Results In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.

Full Text of Discussion Current treatment algorithms for the prevention of myocardial infarction, stroke, and death from cardiovascular causes recommend statin therapy for article source with established vascular disease, diabetes, and overt hyperlipidemia. Measurement of high-sensitivity C-reactive protein, an inflammatory biomarker that independently predicts future vascular events, improves global classification of risk, regardless of the LDL cholesterol level.

To date, however, no prospective outcome trial has directly addressed the question of whether apparently healthy persons with levels of LDL cholesterol below current treatment thresholds but with elevated levels of high-sensitivity C-reactive protein might benefit from statin therapy.

The primary objective of the Justification for the Use click the following article Statins in Prevention: JUPITER was a randomized, double-blind, placebo-controlled, multicenter trial conducted at sites in 26 countries see the Supplementary Appendixavailable with the full text of this this web page at www.

The trial protocol was designed and written by the study chair and rapa für Psoriasis by Psoriasis Körper Symptome Foto auf den local institutional review board at each participating center.

The trial data were analyzed by the academic study statistician and the academic programmer. The academic authors vouch for the accuracy and completeness of the data and the analyses. The trial was financially supported by AstraZeneca. The sponsor collected the trial data and monitored rapa für Psoriasis study sites but played no role in the conduct of the analyses or drafting of the manuscript and had no access to the unblinded trial data until after the manuscript was submitted for publication.

As described in detail elsewhere, rapa für Psoriasis men 50 years of age or older and women 60 years of age or older were eligible for the trial if they did not have a history of cardiovascular disease rapa für Psoriasis if, at the initial screening rapa für Psoriasis, they had an LDL cholesterol level of less than mg per deciliter 3.

Other requirements for inclusion were a willingness to participate for the duration of the trial, provision of written informed consent, and a triglyceride level of less than mg per deciliter 5. Exclusion criteria were previous or current use of lipid-lowering therapy, current use of postmenopausal hormone-replacement therapy, evidence of hepatic dysfunction an alanine aminotransferase level that was more than twice the upper limit of the normal rangea creatine kinase level that was more than three times the upper limit of the normal range, a creatinine level that was higher than 2.

Because a core scientific hypothesis of the trial concerned the role of underlying low-grade inflammation as evidenced by elevated high-sensitivity C-reactive protein levels, patients rapa für Psoriasis inflammatory conditions such as severe arthritis, lupus, or inflammatory bowel disease were excluded, as were patients taking immunosuppressant agents such as cyclosporine, tacrolimus, azathioprine, or long-term oral glucocorticoids. All potentially eligible subjects underwent a 4-week run-in phase during which they received placebo.

Only subjects who successfully completed the run-in phase were enrolled. Eligible subjects were randomly assigned in a 1: Randomization was performed with the use of an interactive voice-response system and was stratified according to center.

Follow-up visits were scheduled to occur at 13 weeks and then 6, 12, 18, 24, 30, 36, 42, 48, 54, and 60 months after randomization. A closeout visit occurred after study termination. Follow-up assessments included laboratory evaluations, pill counts, and structured interviews assessing outcomes and potential adverse events.

Measurements of lipid levels, high-sensitivity C-reactive protein levels, hepatic and renal function, blood glucose levels, and glycated hemoglobin values were performed in a central laboratory. Personnel at each site also contacted their participants midway between scheduled visits to evaluate their well-being and to maintain study participation.

The primary outcome was the occurrence of a first major cardiovascular event, defined as nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina, an arterial revascularization procedure, or confirmed death from cardiovascular causes. Secondary end points included the components of the primary end point considered individually — arterial revascularization or hospitalization for unstable angina, myocardial infarction, stroke, or death from cardiovascular causes — and death from any cause.

All reported primary end points that occurred through March 30,were adjudicated on the basis of standardized criteria by an independent end-point committee unaware of the randomized treatment assignments. Only deaths classified as clearly due to cardiovascular welche schädlich für Psoriasis cerebrovascular causes by the end-point committee were included in the analysis of the primary end point.

For the end point of death from any cause, all deaths were included, regardless of whether data were available to confirm the rapa für Psoriasis of death. Pretrial estimates of the duration of follow-up and number of participants were based on event rates in earlier prevention trials 19,20 and were modified to click into account plans to include low-risk groups, including women.

The stopping boundary was crossed at the first prespecified efficacy evaluation, and on March 29,the independent data and safety monitoring board voted to recommend termination of the trial.

This recommendation took into account the size and precision of the observed treatment benefit, as well as effects on the rates of death and other secondary end points being monitored and on major subgroups. Although the trial ended on March 30,when the steering committee formally accepted this recommendation, we continued the adverse-event reporting in a blinded manner for each study participant until the date he or she appeared for a formal closeout visit and discontinued therapy.

All primary analyses http://festival-celle.de/beide-haende-sieht-psoriasis.php performed on an intention-to-treat basis. Study participation was considered to be complete for any individual participant at the time he or she had an occurrence of the primary end point, had informed consent withdrawn, was unable to be followed further because the study site closed, or had been followed through at least March 30, The exposure time was calculated as the time between randomization and the first major cardiovascular event, the date of death, the date of the last study visit, the date of withdrawal or loss to follow-up, or March 30,whichever came first.

Prespecified subgroup analyses were performed according to the presence or absence of major rapa für Psoriasis risk factors. Between February 4,and December 15,a total of 89, people were screened for enrollment. Of these, 72, were ineligible, including 37, Other reasons for exclusion are presented in Figure 1 rapa für Psoriasis the Supplementary Appendix. A total of 17, people were randomly assigned to a study group.

By design, the study population was diverse; of the 17, participants were women Aspirin was used by Among those assigned to rosuvastatin, the median LDL cholesterol level at 12 months was 55 mg per deciliter 1. These effects persisted throughout the study period. At the time of study termination median follow-up, 1. Panel A shows the cumulative incidence of the primary end point nonfatal myocardial infarction, nonfatal stroke, arterial http://festival-celle.de/wachteleier-in-psoriasis-ob-es.php, hospitalization for unstable angina, or confirmed death from cardiovascular causes.

The hazard ratio for rosuvastatin, as compared with placebo, was 0. Panel B shows the cumulative incidence of nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes, for which the hazard ratio in the rosuvastatin group was 0.

Panel C shows the cumulative incidence of arterial revascularization or hospitalization for unstable angina, for which the hazard ratio in the rosuvastatin group was 0.

Panel D shows the cumulative incidence of death from any cause, for which the hazard ratio in the rosuvastatin group was 0. In each panel, the inset shows rapa für Psoriasis same data on an enlarged y axis and on a condensed rapa für Psoriasis axis.

In a test for interaction between the study-group assignment and follow-up time, there was no significant violation of the proportional-hazards assumption. On the basis of Kaplan—Meier estimates Figure 1the number of patients who would need to be treated with rosuvastatin for 2 years to prevent the occurrence of one primary end point rapa für Psoriasis 95, and the number needed to treat for 4 years is Rapa für Psoriasis 4-year risks are projected over an average 5-year treatment period, as has been commonly done in previous statin trials according to the method of Altman and Andersen, 22 the number needed to treat to prevent the occurrence of one primary end point is Rosuvastatin was also associated with significant reductions in rates of the individual components of the primary trial end point.

For the end point of fatal or nonfatal myocardial click here, event rates were 0.

The corresponding rates were 0. In addition, the rates of death from any cause were 1. In analyses limited to deaths for which the date of death was known with certainty, there was a similar reduction in the hazard ratio associated with rosuvastatin 0. For the primary end point, there was no evidence Allergie Hautausschlag heterogeneity in the results for any subgroup evaluated.

The primary end point was the combination of nonfatal myocardial Creme Psoriasis für Gesundheit, nonfatal stroke, arterial revascularization, hospitalization for unstable angina, or confirmed death from cardiovascular causes. The dashed vertical line indicates the overall relative risk reduction for the complete trial cohort.

Also shown rapa für Psoriasis the P values for the test of an interaction between the primary end point and the categories within each subgroup. For the ordinal variables, interaction tests considered a trend across the subgroup categories with integer scores applied to these categories.

Data were missing for some participants rapa für Psoriasis some subgroups. The body-mass index BMI is the weight in kilograms divided by the square of the height in meters. CHD denotes coronary heart disease. The metabolic syndrome was defined according to consensus criteria of the American Heart Association and the National Heart, Lung, rapa für Psoriasis Blood Institute. Race or ethnic group was self-reported.

Groups typically assumed to be at very low risk also benefited. For subjects with elevated high-sensitivity C-reactive protein levels but no other major risk factor other than increased age, the benefit of rosuvastatin rapa für Psoriasis similar to rapa für Psoriasis for higher-risk subjects hazard ratio, 0.

After closure of the trial, one nonfatal case of rhabdomyolysis was reported in a year-old participant with febrile influenza, pneumonia, and trauma-induced myopathy who was in the rosuvastatin group listed in Table 4.

There were no significant differences between the two study groups with regard to muscle weakness, newly diagnosed cancer, or disorders of rapa für Psoriasis hematologic, gastrointestinal, hepatic, or renal systems.

With regard to direct measures of safety, rates of elevation of the alanine aminotransferase level to more than three rapa für Psoriasis the upper limit of the normal range were similar in the two groups.

Median glomerular filtration rates at 12 months were Protocol-specified measurements rapa für Psoriasis no significant differences between rapa für Psoriasis study groups during the follow-up period with respect to the fasting blood glucose level 98 mg per deciliter [5. Nevertheless, rapa für Psoriasis diabetes was more frequent in the rosuvastatin group reports of diabetes, vs. In this randomized trial of apparently healthy men and women with elevated levels of high-sensitivity C-reactive protein, rosuvastatin significantly reduced the incidence of major cardiovascular events, despite the fact that nearly all study participants had lipid levels at baseline that were well below the threshold for treatment according to current prevention guidelines.

Rosuvastatin also significantly reduced the incidence of death rapa für Psoriasis any cause. The trial also showed robust reductions in cardiovascular events with statin therapy in women and black and Hispanic populations for which data on primary prevention are limited. However, the reduction in the hazard seen in our trial, in which enrollment was based on elevated high-sensitivity C-reactive protein levels rather than on elevated LDL cholesterol levels, was almost twice this magnitude and revealed a greater relative benefit than rapa für Psoriasis found in most previous statin trials see Figure 2 in the Supplementary Appendix.

Since the median follow-up of subjects was 1. However, no such increase was detected in an analysis of participants rapa für Psoriasis continued to receive treatment for 4 or more years.

Rapa für Psoriasis did detect a small but significant increase in the rate of physician-reported diabetes with rosuvastatin, as well as a small, though significant, increase in the median value of glycated hemoglobin. Increases in glucose and glycated hemoglobin rapa für Psoriasis, the incidence of newly diagnosed diabetes, and worsening glycemic control have been reported in previous trials of pravastatin, simvastatin, and atorvastatin.

Therefore, although the increase in the rate of physician-reported diabetes in the rosuvastatin group could reflect the play of chance, further study is needed before any causative effect can be established or refuted. Potential limitations of our study merit consideration. Thus, a trial of statin therapy involving people with rapa für Psoriasis low cholesterol and low high-sensitivity C-reactive protein levels would have been not only infeasible in terms of statistical power and sample size but also highly unlikely to show a article source. Second, since the trial was stopped early by the independent data and safety monitoring board after a median follow-up of less than 2 years, the effect of longer-term therapy should be considered.

We verified that the assumption of proportional hazards was not violated during the follow-up period, and we found a robust benefit of rosuvastatin in analyses restricted to events occurring more than 2 years after randomization. The strategy also could reduce the UFO Psoriasis Bewertungen for imaging tests in asymptomatic populations. On the other hand, our trial evaluated the use of rosuvastatin for the prevention of first cardiovascular events; therefore, the absolute event rates are lower than Kombination Heviz Behandlung von Psoriasis ist be expected among patients with a history of vascular disease, a fact that should be taken into account in considering whether the use of statin therapy among those with low LDL cholesterol levels but elevated high-sensitivity C-reactive protein levels would be cost-effective if applied widely.

With regard to the inflammatory hypothesis of atherothrombosis, our trial involved an agent that is highly effective at reducing levels of both cholesterol and high-sensitivity C-reactive protein. In previous work, achieving low levels of both LDL cholesterol and high-sensitivity C-reactive protein appears to have contributed to the clinical benefit of statin therapy. In conclusion, in this randomized trial of apparently healthy men and women who did not have hyperlipidemia but did have elevated levels of high-sensitivity C-reactive protein, the rates rapa für Psoriasis a first major cardiovascular event and death from any cause were significantly reduced among the participants who received rosuvastatin as compared rapa für Psoriasis those who received placebo.

These patents have been licensed to Dade Behring article source AstraZeneca. Fonseca reports receiving research grants, lecture fees, and consulting fees from AstraZeneca, Pfizer, Schering-Plough, Sanofi-Aventis, and Merck; and Just click for source. Genest, lecture fees from AstraZeneca, Schering-Plough, Merck—Schering-Plough, Pfizer, Novartis, and Sanofi-Aventis rapa für Psoriasis consulting fees from AstraZeneca, Rapa für Psoriasis, Merck Frosst, Schering-Plough, Pfizer, Novartis, Resverlogix, and Sanofi-Aventis.

Gotto reports receiving consulting fees from Dupont, Novartis, Aegerion, Arisaph, Kowa, Merck, Merck—Schering-Plough, Pfizer, Genentech, Martek, and Reliant; serving as an expert witness; and receiving publication royalties.

Kastelein reports receiving grant support from AstraZeneca, Pfizer, Roche, Novartis, Merck, Merck—Schering-Plough, Isis, Genzyme, and Sanofi-Aventis; lecture fees from AstraZeneca, GlaxoSmithKline, Pfizer, Novartis, Rapa für Psoriasis, Roche, Rapa für Psoriasis, and Boehringer Ingelheim; and consulting fees from AstraZeneca, Abbott, Pfizer, Isis, Genzyme, Roche, Novartis, Merck, Merck—Schering-Plough, and Sanofi-Aventis.

Koenig reports wie mit Psoriasis beschäftigen grant support from AstraZeneca, Roche, Anthera, Dade Behring and GlaxoSmithKline; lecture fees from AstraZeneca, Pfizer, Novartis, GlaxoSmithKline, DiaDexus, Roche, and Boehringer Ingelheim; and consulting fees from GlaxoSmithKline, Medlogix, Anthera, and Roche.

Libby reports receiving lecture fees from Pfizer and lecture rapa für Psoriasis consulting fees from AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Merck, Pfizer, Sanofi-Aventis, VIA Pharmaceuticals, Interleukin Genetics, Kowa Research Visit web page, Novartis, and Merck—Schering-Plough.

Lorenzatti reports receiving grant support, lecture fees, and consulting fees from AstraZeneca, Takeda, and Novartis; Dr. Nordestgaard, lecture fees from AstraZeneca, Sanofi-Aventis, Pfizer, Boehringer Ingelheim, and Merck and consulting fees from AstraZeneca and BG Medicine; Dr. Shepherd, lecture fees from AstraZeneca, Pfizer, and Merck rapa für Psoriasis consulting fees from AstraZeneca, Merck, Roche, GlaxoSmithKline, Pfizer, Nicox, and Oxford Biosciences; and Dr.

Glynn, grant support from AstraZeneca and Bristol-Myers Squibb. No other potential conflict of interest relevant to this article was reported. We invite readers to submit comments on the JUPITER trial in a rapa für Psoriasis interactive feature, Clinical Directions — The JUPITER Trial: Will You Change Your Practice?

Commenting closes November 26, We thank the 17, study participants, their individual physicians, and the medical and clinical teams at AstraZeneca for their rapa für Psoriasis time and commitment to this project. From the Center for Cardiovascular Disease Prevention P. Address reprint requests to Dr.

Members of the Justification for Psoriasis kann geheilt werden, Use of Statins in Prevention: Committee and board members for Rapa für Psoriasis were as follows: Steering Committee — Rapa für Psoriasis. Ridker principal investigator and trial chairF. Willerson; Clinical Coordinating Center — P. Ridker chair rapa für Psoriasis, E. Glynn; Independent Data and Safety Monitoring Board — R.

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Precision and Future Medicine 1: Daniel Medeiros Moreira, Maria Emilia Lueneberg, Roberto Leo da Silva, Tammuz Fattah, Carlos Antonio Mascia Gottschall. Journal of Cardiovascular Pharmacology and Therapeutics Ronen Arbel, Dan Greenberg.

Vincent Pialoux, Marc J. Chirico, Camille Faes, Darlene Y. Frontiers in Physiology 8. EMC - Tratado de Medicina EMC - Rapa für Psoriasis - Trattato di Medicina Mateja Kaja Jezovnik, Jawed Fareed, Pavel Poredos.

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Biomarkers of diabetes in Tunisians metabolic syndrome patients. Cytokine 86 European Journal of Clinical Pharmacology Is there a role for emerging anti-inflammatory interventions?. Willig, Edgar Turner Overton. A Review of the Evidence. Emma Kaplan-Lewis, Judith A. Statins for Inflammatory Bowel Disease: Expanding the Scope of Prevention. The American Journal of Gastroenterology Divyesh Thakker, Sunita Nair, Amit Pagada, Vinayak Jamdade, Anuradha Malik. Daniel I Swerdlow, Karoline B Kuchenbaecker, Sonia Shah, Reecha Sofat, Michael V Holmes, Jon White, Jennifer S Mindell, Mika Kivimaki, Eric J Brunner, John C Whittaker, Juan P Casas, Aroon Bewertungen Salbe aus Psoriasis Hingorani.

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Лечебная грязь SIVASH стала известной и была признана медицинским продуктом благодаря стараниям Владимира Виговского, который сам болен псориазом. При помощи грязи он получил значительное облегчение и смог добиться длительной ремиссии. Посмотрите видео и внесите свой емайл-адрес в форму ниже, чтобы посмотреть интервью с Владимиром Виговским и получить дополнительную интересную информацию rapa für Psoriasis лечебной грязи SIVASH! SIVASH-Heilerde - это rapa für Psoriasis лечебная грязь морской илкоторая образовалась в сильно соленасыщенной розовой рапе залива Сиваш северная часть Крыма и представляет собой сложную физико-химическую динамическую систему.

По своим физико-химическим показателям SIVASH-Heilerde относится к соленасыщенным, слабосульфидным, хлоридно-магниево-натриевым пелоидам. Кроме ценных минералов она содержит определенные биологические составляющие имеет слабый запах сероводорода. Аналогов в мире ей нет. SIVASH-Heilerde добывается из озера вручную, расфасовывается без переработки и добавления консервантов, лишь заливается сверху розовой рапой Сиваша и плотно закрывается. Так она доставляется к пользователю в своем натуральном виде.

Высокая концентрация соли защищает грязь абсолютно натурально от микробов. Розовый цвет сильно концентрированная рапа Сиваша имеет благодаря очень полезной микроводоросли Дуналиела Салинавырабатывающей большое количество бета-каротина. Продолжительность процедуры может составлять около мин.

После чего смыть грязь теплой водой. Смывать грязь рекомендуется при помощи SIVASH-Heilerde Mineral Waschgel. Тогда на коже не остается ощущение стянутости после использования солесодержащей rapa für Psoriasis. Также при ежедневном умывании и принятии душа рекомендуется пользоваться мягкими очищающими продуктами This web page на основе грязи. Можно rapa für Psoriasis место нанесения грязи накрыть пленкой, а через полчаса пленку снять и смыть грязь.

В данном случае грязь остается влажной и легче смывается. Мы рекомендуем набрать грязь из банки шпателем и положить в центр rapa für Psoriasis большого куска пленки и сформировать пленку в мешочек. Грязь нанести на кожу непосредственно с пленки и место нанесения накрыть этим же куском пленки.

Перед первой процедурой лечения рекомендуется нанести грязь раза на ступни rapa für Psoriasis 10 минут. Псориаз - это хроническое незаразное заболевание кожи с ускоренным образованием верхнего слоя кожи и его шелушения.

Сильно шелушащиеся участки кожи чаще всего небольшого размера до величины с ладонь. Псориаз проявляется часто на коленях, локтях и голове, а также через изменения на ногтях. Часто псориаз не вызывает болезненных ощущений. Но иногда проявления его настолько тяжелые, что качество жизни больного значительно ухудшается.

Благодаря очень мелкой структуре SIVASH-Heilerde происходит массаж поверхности кожи и раздражение большого количества рецепторов. Это ведет rapa für Psoriasis улучшению кровоснабжения и усилению потоотделения. Ороговелые частицы кожи обволакиваются и мягко устраняются, уменьшается зуд. Лечебная грязь обладает высокой минерализацией с большей частью хлоридно-магниево-натриевых ионов. Благодаря ионному обмену иловая грязь обогащает кожу минералами. При проникновении минералов псориатическая кожа снабжается недостающим солями магния и наступает ослабление симптомов заболевания, таких this web page зуд.

При этом ионы магния вытесняют ионы кальция из check this out соединений. Этот эффект также известен из лечения кожных заболеваний на Мертвом море. Click at this page является хорошим накопителем тепла и может применяться как rapa für Psoriasis теплом так и в холодном виде.

Организм стремится выровнять различие температуры, что ведет к началу оздоровительного процесса. SIVASH-Heilerde образуется в насыщенном соленом растворе и поэтому сама лечебная грязь содержит много соли. Соль, как check this out, отнимает у вредных микроорганизмов среду обитания - воду и оказывает бактерицидное воздействие также на бактерии, способствующие возникновению воспалений на коже при псориазе Info.

SIVASH-Heilerde является сульфидной грязью и, соответственно, содержит серу. Сера применяется уже с давних времен при проблемах с кожей Info. Она оказывает антибактериальное воздействие, устраняет ороговелости и регулирует чрезмерное образование подкожного жира Info.

Наружно рецепты с серой назначаются при акне rapa für Psoriasis, экземахчесоткемикозах Info. Это фотографии Владимира Виговского, человека, который инициировал научные исследования rapa für Psoriasis грязи SIVASH. Он добился этого успешного результата в течение 2 месяцев. Виговский заботится о гостях, приезжающих летом лечиться на соленое озеро Сиваш и выглядит следующим образом в центре:. Применялась SIVASH-Heilerde и жидкое rapa für Psoriasis на ее основе.

Мелкие псориазные пятна по всему тело и голове, включая волосистую часть. Владимир Виговский, врач Надежда Волошко и пациентка, испытавшая действие грязи на себе. Разговор идет rapa für Psoriasis украинском и русском языках.

Powered by Drupal and Drupal Theme created with Artisteer. Целебная сила соленого озера SIVASH-Heilerde rapa für Psoriasis Meer-Badesalz. Проект SIVASH Озеро Сиваш Лечебная грязь Продукты SIVASH Методы лечения Действие грязи Способ применения Артроз Артрит Подагра Межпозвонковая грыжа Перенапряжение мышц Ушибы и вывихи Гигрома на стопе Гигрома на запястье Гигрома на пальце Акне, угри Дерматит Псориаз Целлюлит Прыщи на лице В массажной практике Помощь в Карлсруэ rapa für Psoriasis угрях Лечебные солевые ванны Impressum Datenschutz.

Главная Использование лечебной грязи SIVASH.


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Original Article. Obesity and the Metabolic Syndrome in Children and Adolescents. Ram Weiss, M.D., James Dziura, Ph.D., Tania S. Burgert, M.D., William V.
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Original Article. Obesity and the Metabolic Syndrome in Children and Adolescents. Ram Weiss, M.D., James Dziura, Ph.D., Tania S. Burgert, M.D., William V.
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Original Article. Obesity and the Metabolic Syndrome in Children and Adolescents. Ram Weiss, M.D., James Dziura, Ph.D., Tania S. Burgert, M.D., William V.
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Original Article. Obesity and the Metabolic Syndrome in Children and Adolescents. Ram Weiss, M.D., James Dziura, Ph.D., Tania S. Burgert, M.D., William V.
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